Saint Joseph's College is accredited by the New England Association of Schools & Colleges, Inc., a non-governmental, nationally recognized organization. Accreditation of an institution by the New England Association indicates that the college meets or exceeds criteria for the assessment of institutional quality periodically applied through a peer group review process. An accredited school or college is one that has available the necessary resources to achieve its stated purposes through appropriate educational programs, is substantially doing so, and gives reasonable evidence that it will continue to do so in the foreseeable future. Institutional integrity is also addressed through accreditation.

The baccalaureate and master’s nursing programs at Saint Joseph's College are accredited by the Commission on Collegiate Nursing Education, One Dupont Circle, NW, Suite 530, Washington, DC 20036, 202-887-6791. The pre-licensure baccalaureate program is approved by the Maine State Board of Nursing.

The online long-term care administration program is also accredited by the National Association of Boards of Examiners of Long-Term Care Administrators.

The online health information management program is accredited by the Commission on Accreditation for Health Informatics and Information Management Education (CAHIIM).